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Beware of antibodies to hGH |
| 1. |
What are antibodies? |
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when you inject proteins different from the natural form, it will cause antibody formation. These antibodies will start to neutralize the protein you are injecting and it is the body¡¯s protection mechanism again foreign invasion. |
| 2. |
How does antibodies work? |
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Natural hGH has 191 amino acids. Therefore, when you injecting 192 amino acid hGH, your body will form antibodies against the strange hGH and gradually stops your hGH from functioning. |
| 3. |
Why must we be careful about using cheap low quality hGH brands? |
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People found that some low quality cheap brands, containing large amount of E.coli host protein contaminations (because their manufacturers did not purify enough to save cost ), also raise large amount of antibodies to the hGH. These antibodies will also gradually stop the body¡¯s hGH from functioning. Therefore, always be careful about using cheap low quality hGH brands. Typically these low quality hGH will still function as normal hGH in the beginning, but in the long run they are bad to the human body. |
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TABLE: Rate of antibody formation for different brands of hGH |
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Brand Name/ Manufacturer |
Cases of developing antibodies |
Rates of developing antibodies |
Nutropin™ / Genentech ¢Ù |
0 / 446 |
0 |
Saizen™/ Serono ¢Ù
|
4 / 310 |
1% |
Humatrope™/ Eli Lilly ¢Ù
|
5 / 314 |
1.6% |
Jintropin™/ GenSci ¢Ù
|
1 / 61 |
1.6% |
Genotropin™/ Pharmacia AB¢Ù
|
8 / 413 |
1.9% |
Hygetropin™/Zhuhai Hengtong ¢Ú
|
12 / 61 |
19.7% |
Shanghai Institutes for Biological Sciences ¢Û |
26 / 62 |
41.9% |
Ansomone™ / AnkeBio ¢Ü |
26 / 62 |
41.9% |
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From the above table, we can find that the antibody formation rate for Jintropin™ is much lower than other domestic hGH brands, and it is very close to the international hGH name brands.
Reference:
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| ¢Ù |
Genotropin™ PI, Humatrope™ PI, Saizen™ PI, Nutropin™ and Nutropin AQ™ PI; |
| ¢Ú |
Pan Huiru,Chen Jiqing, Zhang lina, et al. Effect of treatment of growth hormone |
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deficiency with domestic recombinant human growth hormone.J Appl Clin Pediatr, September 2001,Vol. 16 No.5. |
| ¢Û |
Yu Yerong, Pan Huiru, Wang Defen, et al. Clinical research of treatment of growth |
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hormone deficiency with domestic recombinant human growth hormone. Chin J Endocrinol Metab, April 1999, Vol 15, No.2. |
| ¢Ü |
Qin Shuwen, Shi Yifan, Wang Defen, et al. A prospective study of therapeutic effect |
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of recombinant human growth hormone in idiopathic growth hormone deficient children before adolescence. Chin J Endocrinol Metab, February 1999, Vol 15, No. 1. |
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